| Pair Name | Triptolide, Carboplatin | ||
| Phytochemical Name | Triptolide (PubChem CID: 107985 ) | ||
| Anticancer drug Name | Carboplatin (PubChem CID: 426756 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Triptolide, Carboplatin | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Down-regulation | Activity | NR1H2 | hsa7376 |
| In Vitro Model | A-375 | Amelanotic melanoma | Homo sapiens (Human) | CVCL_0132 |
| B16 | Mouse melanoma | Mus musculus (Mouse) | CVCL_F936 | |
| In Vivo Model | A375 cells were resuspended in 40% Matrigel (BD Biosciences) on ice, and then injected subcutaneously into the right axilla of the nude mice. | |||
| Result | This study reveals the NER inhibitor TPL which has great potential in treating melanoma, either alone or in combination with CBP. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma. Front Pharmacol. 2023 Jun 1;14:1157433. doi: 10.3389/fphar.2023.1157433. | Click |
